Status:
WITHDRAWN
The Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children
Lead Sponsor:
Johann Wolfgang Goethe University Hospital
Conditions:
Intrinsic Asthma
Allergic Asthma
Eligibility:
All Genders
3-5 years
Brief Summary
The aim of investigator´s clinical trial is to investigate 52 patients aged three to five years with viral-induced asthma and 52 patients aged three to five years with allergic asthma. Over a time-spa...
Detailed Description
A positive family history with prevalence of atopy, eczema, wheezing are well-known factors predicting asthma. Caudri et al. found more important predictors like perinatal transmission, parental use o...
Eligibility Criteria
Inclusion
- informed consent
- age 3 to 6 years
- diagnosis asthma
- pulmonary function: FEV1 (% pred.)≥ 70%
- ability to carry out 2 reproducible flow volume loops
- moderate to severe BHR (PD20 FEV1 ≤ 0,3 mg methacholine)
- more than 4 weeks interval since last infection
- 8 hours washout period of Short Acting Beta Agonist
- 1 week washout period of Ipratropium Bromide
- 1 week washout period of Long Acting Beta Agonist
- 4 weeks washout period of Systemic Corticosteroids
- 4 weeks washout period of Leukotriene Antagonists
Exclusion
- Age \< 3 and \> 6 Years
- Pulmonary function test: FEV1 (% pred.) \< 70%
- Others chronic diseases or infections (e.g., HIV, tuberculosis, malignancy)
- Incapability to perform spirometry
- Current participation in another clinical trial
Key Trial Info
Start Date :
May 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01144910
Start Date
May 1 2011
End Date
September 1 2017
Last Update
March 3 2017
Active Locations (1)
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1
Goethe University
Frankfurt am Main, Germany, 60590