Status:
COMPLETED
Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes
Lead Sponsor:
Landsteiner Institut
Collaborating Sponsors:
Mein Hanusch-Krankenhaus
Karl-Landsteiner Institute for Endocrinology and Metabolism
Conditions:
Type 2 Diabetes Mellitus
Insulin Resistance
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Life style intervention including diet and exercise is the recommended strategy for prevention of type 2 diabetes mellitus (T2DM). First-degree relatives of patients with type 2 diabetes mellitus have...
Eligibility Criteria
Inclusion
- First degree relatives of type 2 diabetic patients
- Age: 18-50 years
- BMI \<30 kg/m2 (due to limited MR diameter)
- Normal routine lab tests (blood cell count, kidney, liver, pancreas, thyroid and neuromuscular function)
- Availability within the local area throughout the study
- Ability to understand and sign the consent forms
Exclusion
- Current smoking
- Present drug treatment
- Regular exercise training
- Contraindications for MRS studies: claustrophobia and metalliferous implants
- Pregnancy
- HIV or Hepatitis
- Acute disease 2 weeks previous to the examination
- Heart disease
- Hypertension (RR\>140/95)
- Liver disease
- Kidney disease
- Pulmonary disease
- Thyroid disease
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01145092
Start Date
February 1 2006
End Date
March 1 2009
Last Update
June 16 2010
Active Locations (1)
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1
Landsteiner Institute
Vienna, Vienna, Austria, 1140