Status:
COMPLETED
The Effects and Mechanisms of Mindfulness Based Cognitive Therapy (MBCT) on Depressive Symptoms and Depression Relapse
Lead Sponsor:
University of Denver
Collaborating Sponsors:
Stanford University
University of Colorado, Boulder
Conditions:
Major Depressive Disorder
Recurrent
Eligibility:
All Genders
18-55 years
Phase:
PHASE3
Brief Summary
This research proposal is intended to elucidate the efficacy and mechanisms underlying Mindfulness Based Cognitive Therapy (MBCT) in a population in remission from recurrent Major Depressive Disorder ...
Eligibility Criteria
Inclusion
- must comprehend English well
- be 18-55 years of age
- meet enhanced DSM-IV criteria for remission of MDD, recurrent and have a history of three or more previous episodes of DSM-IV major depression in the absence of a history of mania or hypomania
- at least one of those episodes was within the past two years
- participant must be in remission and if on antidepressant medication (ADM), they must be on a stable dose with no change in type or amount for past 12 weeks or participants must be off ADM at T1 for at least the preceding 12 weeks
- have, at screening assessment, residual depressive symptoms indicated by a Beck Depression Inventory-II (BDI-II;\[72\]) score between 6-19.
Exclusion
- bipolar disorder
- schizophrenia or borderline personality disorder
- current suicidal thoughts and/or suicide attempt in last two months
- current anxiety disorder if it constitutes the predominant aspect of the clinical presentation and requires primary treatment not offered in the project
- substance abuse or dependence within last three months
- dementia or subnormal intellectual potential
- current obsessive-compulsive disorder
- current eating disorder
- history of previous mindfulness training or more than eight lifetime sessions of CBT
- current use of psychotherapy or counseling
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT01145872
Start Date
July 1 2010
End Date
April 1 2013
Last Update
December 2 2014
Active Locations (1)
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1
University of Denver
Denver, Colorado, United States, 80208