Status:
COMPLETED
The Study of Ocular Hemodynamics With Glaucoma Progression
Lead Sponsor:
Indiana University
Conditions:
Glaucoma
Eligibility:
All Genders
30+ years
Brief Summary
To determine the relationships between ocular hemodynamics and glaucomatous optic neuropathy progression.
Detailed Description
1. To determine whether baseline ocular blood flow values are predictive of glaucomatous progression as determined by visual field analysis. 2. To determine how changes in ocular blood flow are relate...
Eligibility Criteria
Inclusion
- Patients will meet all of the following inclusion criteria to enter the study:
- Age: 30 years or older.
- Diagnosis: confirmed open-angle glaucoma in at least one eye:
- glaucomatous visual field loss on Humphrey 24-2 or 10-2 perimetry
- glaucomatous optic disc cupping
- agreement between two baseline exams for reliability
- Best corrected visual acuity at least 20/60 in at least one eye.
- Prior Humphrey visual fields demonstrate acceptable reliability standards (see below).
Exclusion
- Extensive Humphrey visual field damage consisting of either a mean deviation (MD) \< -15 decibels or a clinically determined threat to fixation in both hemifields.
- Evidence of exfoliation or pigment dispersion.
- History of acute angle-closure or a narrow, occludable anterior chamber angle by gonioscopy.
- History of chronic or recurrent inflammatory eye diseases (e.g., scleritis, uveitis).
- History or signs of intraocular trauma.
- Severe or potentially progressive retinal disease such as retinal degeneration, diabetic retinopathy, and retinal detachment.
- Any abnormality preventing reliable applanation tonometry.
- Current use of any ophthalmic or systemic steroid which may interfere with this investigation.
- Cataract surgery within the past year.
- Resting pulse \< 50 beats per minute.
- Severe, unstable or uncontrolled cardiovascular, renal, or pulmonary disease.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 3 2014
Estimated Enrollment :
123 Patients enrolled
Trial Details
Trial ID
NCT01145911
Start Date
January 1 2008
End Date
July 3 2014
Last Update
March 7 2017
Active Locations (1)
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1
Indiana University School of Medicine, Department of Ophthalmology
Indianapolis, Indiana, United States, 46202