Status:
COMPLETED
The Effect of Exercise on Peripheral Blood Gene Expression in Angina
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Conditions:
Angina Pectoris
Eligibility:
All Genders
30-80 years
Phase:
NA
Brief Summary
Regular exercise is known to produce significant health benefits and to reduce the risk of heart diseases, although how this benefit occurs is not well understood. White blood cells are known to be in...
Eligibility Criteria
Inclusion
- Class I to III angina pectoris (classified according to the Canadian Cardiovascular Society \[CCS\])with documented myocardial ischemia or coronary artery disease on angiography
- Ability to read and speak English to a level allowing satisfactory completion of written questionnaires and to understand instruction during the exercise programme.
Exclusion
- Acute coronary syndromes or recent myocardial infarction (\<2 months)
- Left main coronary artery stenosis \>25% or high-grade proximal left anterior descending artery stenosis
- Known reduced left ventricular function (ejection fraction \<40%)
- Significant valvular heart disease
- Insulin-dependent diabetes mellitus
- Occupational, orthopedic, and other conditions that preclude regular exercise
- Patients whose ECG prevents interpretation of an exercise test (LBBB, RBBB, pacemaker implantation).
- Patients who already perform greater than 30min continuous exercise three times weekly (self-reported).
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01147952
Start Date
November 1 2010
End Date
May 1 2014
Last Update
April 14 2016
Active Locations (1)
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1
NIHR Cardiovascular Biomedical Research Unit
Sheffield, South Yorkshire, United Kingdom, S5 7AU