Status:
COMPLETED
Effects of Amino Acids on Regional Lipid Metabolism
Lead Sponsor:
University of Arkansas
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Hypertriglyceridemia
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
Elevated fat level in blood is a risk factor for coronary heart disease, a major cause of death in America. The overall goal of this project is to test a novel treatment using nutrient (amino acid) su...
Detailed Description
Coronary heart disease (CHD) remains the single largest killer of American men and women (45). Hyper¬triglyceridemia (elevated triglyceride \[TG\] concentration in the blood) has been shown to be a si...
Eligibility Criteria
Inclusion
- Age 50-75 years.
- Men and Women (Women postmenopausal).
- Ability to sign informed consent, including ≥26 Mini-Mental State Exam.
- Plasma triglyceride concentration between 130-500 mg/dl.
Exclusion
- Diabetes (plasma glucose: fasting ≥126 mg/dl or ≥200 mg/dl at 2 hr after 75 g glucose load).
- On diabetes medication or lipid altering agents, including over the counter fish oil/omega 3 fatty acids.
- Kidney/renal or liver disease.
- Bleeding disorders or anemia.
- Endocrine disease.
- Positive hepatitis or HIV screens.
- Alcohol abuse or drug abuse
- Score of \<26 on the Mini-Mental State Exam.
- Allergy to iodine or fish products.
- Subjects with cerebral aneurysm clips, internal transistorized devices (e.g., neural stimulators), or cardiac pacemakers.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT01150188
Start Date
June 1 2010
End Date
August 1 2016
Last Update
October 27 2016
Active Locations (1)
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1
University of Arkansas for Medical Science, Reynolds Aging Institute
Little Rock, Arkansas, United States, 72205