Status:
UNKNOWN
Role of Biomarkers in Endometrial Cancer Recurrence in Samples From Patients With Stage II, Stage III, or Stage IV Endometrial Cancer
Lead Sponsor:
Gynecologic Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Endometrial Cancer
Eligibility:
FEMALE
Brief Summary
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study i...
Detailed Description
OBJECTIVES: * To investigate the association of endometrioid adenocarcinoma (EA) recurrence with pre-operative serum levels of insulin, total and free insulin-like growth factor-I (IGF-I), IGF-II, in...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed endometrioid endometrial cancer
- Stage II-IV disease
- Patients who were eligible and evaluated on the GOG-0210, Molecular Staging in Endometrial Cancer clinical trial, meeting the following criteria:
- Allowed their specimens and clinical data collected as part of their participation
- Have sufficient high-quality frozen primary tumor, formalin-fixed and paraffin-embedded (FFPE) primary tumor, and/or pre-operative serum for testing available
- Patients who underwent surgical staging as specified in the GOG-0210 protocol and described in the GOG Surgical Manual Protocol, including any of the following procedures:
- Hysterectomy
- Bilateral oophorectomy
- Washings as well as pelvic lymphadenectomy and para-aortic lymphadenectomy
- Non-cancerous endometrial tissue and fasting serum from control samples meeting the following criteria (controls):
- Underwent hysterectomy to treat uterine prolapse at the Albert Einstein Hospital and Montefiore Medical Center, in the Bronx, NY
- No uterine fibroids or prior cancer
- PATIENT CHARACTERISTICS:
- Postmenopausal patients and controls
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
July 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
865 Patients enrolled
Trial Details
Trial ID
NCT01150682
Start Date
July 1 2010
Last Update
April 29 2011
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