Status:
COMPLETED
Comparison of Propofol Based Versus Volatile Based Anesthesia and Postoperative Sedation
Lead Sponsor:
University Health Network, Toronto
Conditions:
Cardiac Surgery
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
All patients undergoing cardiac surgery require intraoperative anesthesia and short-term postoperative sedation with anesthetic agents after the procedure when patient is in the intensive care unit (I...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients scheduled for coronary artery bypass graft surgery with good ventricular function (grade 1-2 ventricle)
- Signed informed consent
- Exclusion criteria:
- Patients undergoing valvular surgery
- Severe kidney or liver disease (creatinine \> 2.5mg.dL-1 and bilirubin \> 2 mg.dL-1)
- Patients with known hypersensitivity to any of the trial drugs (propofol, volatile anesthetics), e.g. propofol allergy or malignant hyperthermia (induced by volatile anesthetics)
- Patient with poorly controlled diabetes or on oral anti-diabetic medication (inhibit preconditioning caused by volatile anesthetics)
Exclusion
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT01151254
Start Date
September 1 2009
End Date
July 1 2013
Last Update
February 12 2014
Active Locations (1)
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1
Toronto General Hopsital
Toronto, Ontario, Canada, M5G 2C4