Status:
COMPLETED
Evaluating Forced Oscillation Technique (FOT) in Abolishing Flow Limitation
Lead Sponsor:
Philips Respironics
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
Up to 80 years
Phase:
NA
Brief Summary
To validate the capability of the Respironics Synchrony ventilator to properly detect Expiratory Flow Limitation (EFL) as compared to the gold standard method of detecting EFL via the Mead and Wittenb...
Detailed Description
Positive end expiratory pressure (PEEP) is used in COPD patients to counteract the intrinsic PEEP (PEEPi), which represents the end expiratory recoil pressure of the total respiratory system due to th...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age \< 80 years
- Moderate - Severe COPD diagnosed by spirometry (according to the GOLD criteria - Global Initiative for Chronic Obstructive Lung Disease criteria)
- Free from any exacerbation in the 6 weeks preceding the study
- Exclusion Criteria
- Any co-existing cardio-pulmonary conditions which may result in a picture of ventilatory failure such as congestive cardiac failure, chest wall or neuromuscular disease, bronchopneumonia, pulmonary fibrosis, bronchiectasis, cystic fibrosis or obesity-hypoventilation syndrome
- Clinically unstable; exacerbation within the preceding 6 weeks
- The presence of pulmonary or extra-pulmonary neoplasia that is still active
- The presence of a bleeding diathesis
- Unstable coronary artery disease
- Presence of tuberculosis, current infection or potentially infectious pathogen
- Inability to provide informed consent to the study
Exclusion
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01151618
Start Date
June 1 2010
End Date
September 1 2010
Last Update
March 18 2019
Active Locations (1)
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1
University Hospital Aintree
Liverpool, United Kingdom, L97AL