Status:
WITHDRAWN
The Role of GLP-1 in Satiety Perception in Humans
Lead Sponsor:
University of Washington
Collaborating Sponsors:
Fred Hutchinson Cancer Center
Conditions:
Appetite Regulation
Obesity
Eligibility:
All Genders
18-29 years
Phase:
NA
Brief Summary
Scientists have discovered a number of hormones that control our feelings of hunger and fullness. One particular hormone, called GLP-1, has been associated with feelings of hunger and fullness. The ov...
Detailed Description
Many times each day, we see food or representations of food and evaluate whether or not the food looks good to us. If it does, we then balance external factors, such as the social situation or time of...
Eligibility Criteria
Inclusion
- Male or female between 18-29 years of age
- BMI between 18.5-24.9 kg/m2
- Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
Exclusion
- Chronic health conditions, including diabetes and kidney disease.
- Current dieting for weight loss or restrained eating
- History of obesity, eating disorders, or weight loss surgery
- Random blood glucose \>140
- Pregnancy or use of oral contraceptives
- Current smoker
- Recreational drug use or alcohol use of \> 1 drink per day for females, \> 2 per day for males
- Food allergy or intolerance to study foods.
- Medications known to alter appetite (e.g., amphetamines, atypical antipsychotics) or gastric emptying (e.g., metoclopromide)
- Contraindications to MRI, such as implanted metal or claustrophobia.
- Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01152333
Start Date
July 1 2010
End Date
July 1 2016
Last Update
June 19 2015
Active Locations (1)
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1
University of Washington
Seattle, Washington, United States, 98195