Status:
COMPLETED
Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease
Lead Sponsor:
Rush University Medical Center
Conditions:
Parkinson's Disease
Multiple System Atrophy
Eligibility:
All Genders
25+ years
Brief Summary
The gut may be a portal of entry for agents that cause or contribute to the causes of Parkinson's disease (PD). The investigators are studying changes in the normal population of gut flora and in inte...
Detailed Description
Clinical and pathological data suggest Parkinson's disease (PD) may result from an inflammatory process beginning in the intestinal wall that initiates alpha-synuclein aggregation, which then spreads ...
Eligibility Criteria
Inclusion
- Inclusion Criteria--Parkinson's disease:
- Clinically diagnosed Parkinson's disease
- Hoehn \& Yahr stage 1-2.5
- No symptomatic treatment of Parkinson's disease symptoms
- Inclusion Criteria--Multiple System Atrophy
- Clinically diagnosed Multiple System Atrophy.
- Inclusion Criteria--Control subjects:
- No diagnosis of Parkinson's disease and no signs of Parkinson's disease on screening neurological examination
- Exclusion Criteria:
- Secondary or atypical parkinsonism other than Multiple System Atrophy
- Occupation or medical treatment known to influence intestinal flora
- Organic gastrointestinal disease other than hiatal hernia or hemorrhoids; history of gastrointestinal surgery other than remote appendectomy or cholecystectomy.
- Acute or chronic medical illness that would confound study results.
- Coagulopathy or use of anticoagulant medications (including aspirin).
- Chronic use of diuretics
Exclusion
Key Trial Info
Start Date :
September 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT01155492
Start Date
September 1 2007
End Date
February 1 2013
Last Update
May 30 2013
Active Locations (1)
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1
Rush University Medical Center
Chicago, Illinois, United States, 60612