Status:
UNKNOWN
Innate Immune Functions of Immature Neutrophils
Lead Sponsor:
University Hospital, Geneva
Conditions:
Sepsis
SIRS
Eligibility:
All Genders
18+ years
Brief Summary
Polymorphonuclear neutrophils, or granulocytes, are essential effector cells of the innate immune system against bacterial infections. Their role in sepsis has been long established as the primary pha...
Detailed Description
Objectives 1. Primary objective: To determine the innate immune functions of immature neutrophils in comparison to those from mature neutrophils, sampled from patients with severe sepsis and sepsis s...
Eligibility Criteria
Inclusion
- Patients with severe sepsis or septic shock (according to ACCP/FCCM standard definitions) with \> 5% immature neutrophils.
- Patients with a noninfectious systemic inflammatory response syndrome (SIRS), e.g. patients with head trauma or multiple trauma with \> 5% immature neutrophils.
- Healthy donors
Exclusion
- Severe immunosuppression (e.g. HIV with \< 200 CD4/mm3), treatment with glucocorticoids (\> 300 mg hydrocortisone/day) or other immunosuppressive therapy
- Neutropenia (neutrophils \< 0.5 G/l).
- Recent chemotherapy or administration of intravenous immunoglobulins within the last 4 weeks.
Key Trial Info
Start Date :
May 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01155674
Start Date
May 1 2010
End Date
October 1 2011
Last Update
July 2 2010
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospitals of Geneva, Intensive Care
Geneva, Switzerland, 1211