Status:
TERMINATED
Phase I Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate Cancer
Lead Sponsor:
Sandy Srinivas
Conditions:
Urologic Neoplasms
Prostate Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Selenium, in the form of inorganic Sodium Selenite, may be useful for treating existing prostate cancer. This idea is based on data from our laboratory showing that 1) prostate cancer cells are more s...
Eligibility Criteria
Inclusion
- Histologically confirmed adenocarcinoma of the prostate
- Castration-resistant prostate cancer requires the following 3 criteria:
- Failure of first line bilateral orchiectomy or therapy with an LHRH agonist,
- A rising PSA on 3 consecutive occasions at least 1 week apart (but not limited to the 30 day screening period), AND
- A castrate level of testosterone (\<50ng/dL)
- PSA doubling time (PSADT) \> 1 months
- Failure on docetaxel chemotherapy as defined by a rising PSA .
- A minimum PSA of 2 ng/mL
- Age \>=18 years
- Life expectancy greater than 6 months
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 or Karnofsky performance status \>=80%
- Bone metastases will be allowed
- The subject has a QTcB (Bazett corrected) or QTcF (Frederica corrected) \< 470 msec.
- Ability to understand and the willingness to sign a written informed consent document.
- Willingness to stay on docetaxel chemotherapy despite rising PSA level.
Exclusion
- Radiotherapy for prostate cancer within 28 days prior to Day 1.
- 2\. More than 1 prior chemotherapy
- 3\. Inadequate organ function, as evidenced by any of the following at screening:
- Absolute neutrophil count (ANC) \< 1500/uL
- Platelet count \<= 100 x 10\^9/L
- Total bilirubin \>= ULN
- AST, and/or ALT \> 1.5 x the upper limit of normal (ULN) with a concomitant alkaline phosphastase \>2.5 X ULN
- Serum creatinine \> 2.0 mg/dL
- Hemoglobin \< 9 g/dL
- 4\. Men with reproductive potential who do not agree to use an accepted and effective method of contraception during the study treatment period and for at least 3 months after completion of the study treatment.
- 5\. History of other malignancies within 5 years prior to Day 1 except for tumors with a negligible risk for metastasis or death, such as adequately controlled basal cell carcinoma, squamous-cell carcinoma of the skin, or early-stage bladder cancer
- 6\. Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study.
- 7\. Known or prior treated brain metastases.
- 8\. History of hypersensitivity to docetaxel
- 9\. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure ,unstable angina pectoris, cardiac arrhythmia, significant vascular disease (e.g. aortic aneurysm, aortic dissection), symptomatic peripheral vascular disease, or psychiatric illness/social situations that would limit compliance with study requirements.
- 10\. History of myocardial infarction or unstable angina within 6 months prior to study enrollment
- 11\. History of stroke or transient ischemic attack within 6 months prior to study enrollment 12. The subject is known to be positive for the human immunodeficiency virus (HIV) and is receiving antiretroviral 12. Willingness to stay on docetaxel chemotherapy despite rising PSA level.
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT01155791
Start Date
April 1 2010
End Date
October 1 2012
Last Update
March 15 2017
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305