Status:
COMPLETED
Metabolism of NNK Among African Americans
Lead Sponsor:
Masonic Cancer Center, University of Minnesota
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Lung Cancer
Eligibility:
All Genders
21-65 years
Brief Summary
Metabolism and DNA adduct formation are critical in cancer induction by NNK. The investigators goal is to understand whether the observed ethnic/racial differences in lung cancer incidence are due to ...
Detailed Description
Lung cancer is the most common cause of cancer death in the United States, with the annual number of cases estimated at 162,460 deaths per year. It is more prevalent in African Americans as compared t...
Eligibility Criteria
Inclusion
- Male or female subjects with a smoking history of at least 10 cigarettes daily for at least 1 year;
- Subjects report themselves, biological parents and both sets of biological grandparents as
- African American or African descent or
- European American or European descent
- Subjects are in apparently good physical health (no unstable medical condition)
- Subjects are in stable, good mental health (e.g. not currently, within the past 6 months, experiencing unstable or untreated psychiatric diagnosis, including substance abuse, as determined by the PRIME-MD);
- Subjects have provided written informed consent to participate in the study.
Exclusion
- Unstable medical conditions including cancer, coronary heart disease and arrhythmia
- Cannot or unwilling to identify ethnic/racial ancestry
- Women who are currently pregnant or breast feeding
- Currently using any other tobacco or nicotine-containing product
- Currently taking any medications that affect relevant metabolic enzymes.
Key Trial Info
Start Date :
December 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2017
Estimated Enrollment :
161 Patients enrolled
Trial Details
Trial ID
NCT01158456
Start Date
December 1 2010
End Date
November 1 2017
Last Update
April 10 2023
Active Locations (1)
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1
Tobacco Research Programs University of Minnesota
Minneapolis, Minnesota, United States, 55414