Status:
COMPLETED
Genes Influencing Iron Overload State
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Sickle Cell Disease
Thalassemia
Eligibility:
All Genders
Brief Summary
Iron overload, which can be defined operationally as too much iron in the body, develops as a consequence of too many blood transfusions given, or due to genetic defects hereditary hemochromatosis). I...
Detailed Description
This study will focus on the following primary objective: * To investigate the association of GSTM1 gene deletion and liver iron concentration in patients with sickle cell disease and transfusional i...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- History of ≥ 12 lifetime erythrocyte transfusions who have not yet initiated treatment to unload iron (iron chelation or therapeutic phlebotomy), or
- History of ≥ 12 lifetime erythrocyte transfusions who have initiated treatment to unload iron, but had liver iron content measurement (by R2\*MRI) within 3 months prior to initiation of iron unloading treatment
- Exclusion Criteria
- Known contraindication to performance of MRI (e.g.: presence of MRI-incompatible ferromagnetic material in the body)
- Prior participation on the St. Jude MRIRON protocol
Exclusion
Key Trial Info
Start Date :
September 21 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 17 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01158794
Start Date
September 21 2010
End Date
April 17 2019
Last Update
September 18 2019
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105