Status:
ACTIVE_NOT_RECRUITING
Zinc Therapy in Critical Illness
Lead Sponsor:
University of Vermont
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Severe Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Sepsis is a clinical syndrome often caused by a bloodstream infection that results in a common set of symptoms termed systemic inflammatory response syndrome (SIRS). Severe sepsis (sepsis with organ f...
Eligibility Criteria
Inclusion
- Severe sepsis
- Requiring mechanical ventilation
- 18 years or older
Exclusion
- \>36 hours since meeting severe sepsis criteria4
- Expected ICU length of stay \<72 hours
- Pre-existing gastrointestinal disease\*
- Post-cardiac arrest with significant anoxic brain injury
- Creatinine clearance \<40mL/min\*
- Taking zinc supplement during past month\*
- Has received zinc supplementation while hospitalized
- Pregnant or lactating\*
- AIDS with CD4\<200\*
- Previous bone marrow or solid organ transplant\*
- Receiving TPN with added zinc
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT01162109
Start Date
September 1 2010
End Date
December 1 2025
Last Update
February 18 2025
Active Locations (1)
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1
University of Vermont College of Medicine
Burlington, Vermont, United States, 05405