Status:
COMPLETED
Prognostic Value of Interferon Gamma Release Assays in Predicting Active Tuberculosis Among Individuals With, or at Risk of, Latent Tuberculosis Infection
Lead Sponsor:
Public Health England
Collaborating Sponsors:
Imperial College London
Queen Mary University of London
Conditions:
Tuberculosis
Latent Tuberculosis
Eligibility:
All Genders
16+ years
Brief Summary
The objective of this study is to assess the efficacy of the two current TB (tuberculosis) blood tests (Interferon Gamma Release Assays (IGRA)) compared with the standard skin test (Mantoux Tuberculin...
Detailed Description
DESIGN: Prospective cohort study of individuals (\> or = 16 yrs) who are: (a) close contacts of TB cases or (b) new entrants from high incidence countries (\>40/100000). SETTING: London TB clinics. NE...
Eligibility Criteria
Inclusion
- Contacts of all active TB (pulmonary and extrapulmonary) patients. (Contacts will include all individuals with a cumulative duration of exposure of greater than eight hours to the relevant index case in a confined space during the period of infectiousness (prior to initiation of treatment) who attend designated clinics.
- New entrants from high incidence countries (incidence of TB of \>40/100000) who attend designated clinics
Exclusion
- Patients who are unable to give informed consent
- Children under 16 years of age
- Individuals found to have active TB at the time of screening
Key Trial Info
Start Date :
August 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2016
Estimated Enrollment :
10000 Patients enrolled
Trial Details
Trial ID
NCT01162265
Start Date
August 1 2010
End Date
June 30 2016
Last Update
October 1 2020
Active Locations (3)
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1
Ealing Hospital
Southall, London, United Kingdom, UB1 3HW
2
St George's Hospital
Tooting, London, United Kingdom, SW17 0QT
3
Homerton Hospital
London, United Kingdom, E9 6SR