Status:
UNKNOWN
Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries
Lead Sponsor:
St George's Healthcare NHS Trust
Conditions:
Endothelial Dysfunction
Atherosclerosis
Eligibility:
All Genders
35+ years
Phase:
NA
Brief Summary
The investigators are hoping to discover the cause of chest pain in patients with a normal coronary arteriogram. For patients with chest pain coronary angiography is the standard method by which the b...
Detailed Description
This study comprises two parts: 1. Blood sample 2. ACH-test (including coronary flow measurements) Blood will be taken, frozen and stored for up to 5 years. The following markers will be studied: C-...
Eligibility Criteria
Inclusion
- Adults of either gender \> 35 years of age with a stable pattern of angina pectoris suggestive of coronary artery disease, with positive responses to exercise stress testing AND/OR patients with chest pain and ischaemic ST-segment changes during pain (previous obstructive coronary artery disease with or without stent-implantation will be allowed).
- Subjects will be invited to participate only if investigations have been undertaken to rule out non-cardiac causes for chest pain (i.e. oesophageal and musculoskeletal) previously.
- Serum creatinine \< 123.7µmol/L.
- Left ventricular ejection fraction \> 50%.
Exclusion
- Chronic obstructive pulmonary disease.
- Cardiomyopathy.
- Severe valvular heart disease.
- Myocardial infarction within the last 3 months.
- Pregnant or lactating women.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01162824
Start Date
January 1 2011
End Date
December 1 2011
Last Update
February 23 2011
Active Locations (1)
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1
Department of Cardiology, St George's Healthcare NHS Trust
London, England, United Kingdom, SW17 0RE