Status:
COMPLETED
Nelfinavir Mesylate and Bortezomib in Treating Patients With Relapsed or Progressive Advanced Hematologic Cancer
Lead Sponsor:
Swiss Cancer Institute
Conditions:
Leukemia
Lymphoma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
RATIONALE: Nelfinavir mesylate and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Bortezomib may also stop the growth of hematologic cancer by b...
Detailed Description
OBJECTIVES: * To assess the safety of nelfinavir mesylate in combination with bortezomib in patients with relapsed or progressive, advanced hematologic malignancies. * To establish the phase II recom...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosed with advanced hematologic malignancies meeting the following criteria:
- Multiple myeloma
- Received ≥ 2 lines of prior chemotherapy (induction chemotherapy followed by high-dose chemotherapy and autologous stem cell transplant with or without maintenance therapy is considered one line of therapy)
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- Mature T- and NK-cell neoplasms restricted to the following WHO-defined entities:
- T-cell prolymphocytic leukemia
- T-cell large granular lymphocytic leukemia
- Aggressive NK-cell leukemia
- Adult T-cell leukemia/lymphoma
- Extranodal NK/T-cell lymphoma (nasal type)
- Mycosis fungoides
- Sézary syndrome
- Primary CD30-positive T-cell lymphoproliferative disorders
- Primary cutaneous anaplastic large cell lymphoma
- Primary cutaneous gamma-delta T-cell lymphoma
- Peripheral T-cell lymphoma (not otherwise specified)
- Angioimmunoblastic T-cell lymphoma
- Anaplastic large cell lymphoma (ALK-positive/ALK-negative)
- Grade 3B follicular lymphoma
- Relapsed following or progressed during standard therapy
- Meeting the following criteria:
- Standard intensive therapy is not feasible
- Current disease state for which there is no standard effective therapy
- Refused standard therapy where no curative option exists
- Measurable disease, defined as the following:
- Myeloma: measurable serum monoclonal protein \> 1 g/dL for IgG, or \> 0.5 g/dL for IgA, IgM or IgD, or difference between involved and uninvolved free light chain levels in serum \> 100 mg/L
- Lymphoma: must have ≥ 1 lesion measurable by CT (longest diameter ≥ 15 mm)
- Acute leukemia: ≥ 20% blasts in bone marrow or in peripheral blood (≥ 200/mL blasts in peripheral blood)
- No HIV-associated lymphoma
- PATIENT CHARACTERISTICS:
- WHO performance status 0-2
- Absolute neutrophil count ≥ 1,500/mm³
- Platelet count ≥ 75,000/mm³ (if bone marrow impairment, ≥ 20,000/mm\^3)
- Hemoglobin \> 80 g/L (if considered to be caused by the underlying hematologic malignancy or bone marrow impairment, \> 80 g/L after transfusion)
- Bilirubin ≤ 1.5 times upper limit of normal (ULN) (if suspected hemolysis, direct bilirubin ≤ 1.5 times ULN)
- ALT ≤ 2.5 times ULN
- Calculated creatinine clearance \> 30 mL/min
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for 12 months after completion of study treatment
- Willing and capable to comply with an oral regimen
- Capable of understanding information given by the investigator on the trial
- Able to adhere and remain in geographic proximity to allow proper staging, treatment, and followup
- No other non-hematologic malignancy within the past 5 years, except adequately treated cervical carcinoma in situ or localized nonmelanoma skin cancer
- No known chronic hepatitis B or C infection or known HIV infection
- No serious underlying medical condition (at the judgment of the investigator) which would impair the ability of the patient to participate in the trial, including any of the following:
- Active autoimmune disease
- Uncontrolled diabetes
- Ongoing or active infection
- Symptomatic congestive heart failure
- Unstable angina pectoris
- Cardiac arrhythmia
- Psychiatric disorder
- No myocardial infarction within the past 6 months
- No polyneuropathy \> grade 1 significantly interfering with activities of daily living or painful polyneuropathy
- No known hypersensitivity to trial drugs or hypersensitivity to any other component of the trial drugs
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No more than 4 prior lines of chemotherapeutic regimens (induction chemotherapy followed by high-dose chemotherapy and autologous stem cell transplant with or without maintenance therapy is considered one line of therapy)
- More than 30 days since prior treatment in a clinical trial
- More than 30 days since prior and no concurrent chemotherapy or biologic agents
- For patients with acute leukemia, hydroxyurea may be given up to 48 hours before first administration of the trial treatment, and low dose cytarabine (up to 20 mg/m\^2) and mitoxantrone up to 20 mg up to 14 days before first dosing
- At least 1 week since prior and no concurrent CYP3A4 modulators
- No concurrent other experimental drugs
- No concurrent radiotherapy
- No concurrent antineoplastic therapy with chemotherapeutic or biologic agents
Exclusion
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01164709
Start Date
July 1 2010
End Date
November 1 2013
Last Update
May 15 2019
Active Locations (4)
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1
Inselspital Bern
Bern, Switzerland, CH-3010
2
Kantonsspital Graubuenden
Chur, Switzerland, CH-7000
3
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland, CH-1011
4
Kantonsspital - St. Gallen
Sankt Gallen, Switzerland, CH-9007