Status:
COMPLETED
ULTrasound Accelerated ThrombolysIs of PulMonAry Embolism
Lead Sponsor:
Boston Scientific Corporation
Collaborating Sponsors:
EKOS Corporation
Conditions:
Submassive Pulmonary Embolism
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
The ULTIMA study is intended to prove that in patients with pulmonary embolism and a right ventricular end diastolic diameter to left ventricular end diastolic diameter ratio ≥1 (RV/LV ratio) will ben...
Eligibility Criteria
Inclusion
- Patients with acute PE symptoms \< 14 days.
- Filling defect by contrast-enhanced chest CT in at least one main or proximal lower lobe pulmonary artery
- Right ventricular dysfunction confirmed by echocardiography where the RV/LV end diastolic diameter ratio is ≥ 1.0.
Exclusion
- Age less than 18 years or greater than 80 years
- Index PE symptom duration \> 14 days
- Insufficient echocardiographic image quality in the apical or subcostal four-chamber view that prohibits the measurement of the right and left ventricular end-diastolic dimensions
- Known significant bleeding risk
- Administration of thrombolytic agents, e.g., tissue plasminogen activator, streptokinase, or urokinase, within the previous 4 days
- Active bleeding
- Known bleeding diathesis
- Known coagulation disorder, platelet count \< 100 000/mm3, or previous use of vitamin K antagonists with INR \> 2.5
- History of any intracranial or intraspinal surgery or trauma or intracranial/intraspinal bleed
- Intracranial neoplasm, arteriovenous malformation, or aneurysm
- Recent (\< 3 months) GI bleeding.
- Recent (\< 3 months) internal eye surgery or hemorrhagic retinopathy; recent (\< 10 days) major surgery, cataract surgery, trauma, CPR, obstetrical delivery, or other invasive procedure.
- Allergy, hypersensitivity, or thrombocytopenia from heparin, rt-PA, or iodinated contrast, except for mild-moderate contrast allergies for which steroid pre-medication can be used.
- Estimated glomerular filtration rate (eGFR) \< 50 ml/min as calculated by the Cockroft formula.
- Hemodynamic collapse at presentation defined as: need for cardiopulmonary resuscitation; or systolic blood pressure \< 90 mm Hg for at least 15 min, or drop of systolic blood pressure by at least 40 mm Hg for at least 15 min with signs of end organ hypoperfusion (cold extremities or low urinary output \< 30 mL/h or mental confusion); or need for catecholamine administration to maintain adequate organ perfusion and a systolic blood pressure of \> 90 mm Hg.
- Severe hypertension on repeated readings (systolic \> 180 mmHg or diastolic \> 105 mmHg).
- Pregnant, lactation or parturition within the previous 30 days (positive pregnancy test, women of childbearing age must be tested).
- Participating in any other investigational drug or device study.
- Life expectancy \< 90 days.
- Inability to comply with study assessments (e.g. due to geographic distance).
- Previous enrollment in this study
- Any other condition that the investigator feels would place the patient at increased risk if the investigational therapy is initiated.
- Known right-to-left shunt, for example from large patent foramen ovale or atrial septal defect
- Large (\>10 mm) right atrial or right ventricular thrombus
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT01166997
Start Date
July 1 2010
End Date
May 1 2013
Last Update
July 19 2021
Active Locations (10)
Enter a location and click search to find clinical trials sorted by distance.
1
Klinikum Lippe-Detmold
Detmold, Germany, 32756
2
Klinikum Dortmund gGmbH
Dortmund, Germany, 44137
3
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Dresden, Germany, 01307
4
Universitätsklinikum der Ernst-Moritz-Arndt-Universität,
Greifswald, Germany, 17475