Status:
COMPLETED
Factors Controlling the Formation of Salivary Films
Lead Sponsor:
Quadram Institute Bioscience
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Brief Summary
The aim of this study is to determine how different ingredients which are found in food and other consumer products affect the ability of saliva to form surface films. Saliva forms a protective film ...
Detailed Description
The aim of this study is to determine the physical and biochemical mechanisms responsible for the formation and structure development (in vitro) of the salivary mucous film and the impact of common in...
Eligibility Criteria
Inclusion
- Age: 18 - 65 years old
- Gender:Male or Female
- nonsmokers
Exclusion
- diabetics
- medical history of Tuberculosis or Hepatitis
- depressed or elevated blood pressure measurements (\<90/50 or \<95/50 if symptomatic or \>160/100).
- take any medication which may affect saliva production
- are related to someone in the study team i.e. spouse, partner or immediate family member
- are pregnant, planning to become pregnant, or are currently breastfeeding.
- have results of the clinical screening which indicate, or are judged by the Human Nutrition Unit (HNU) Medical Advisor to be indicative of, a health problem which compromise the wellbeing of the volunteer if they participated, which would affect the study data.
- In addition, prior to each sample donation, the following conditions will be checked, and volunteers will only be allowed to donate saliva if none of the following apply:
- They have any current dental or mouth problems (bleeding gums, sores on mouth, dry mouth syndrome)
- They have had a viral illness or chest infection within last 7 days
- They are not able to produce sufficient saliva
- Volunteers will be required to avoid eating and drinking (except water) for 1 hour prior to saliva collection.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT01167504
Start Date
June 1 2010
End Date
August 1 2013
Last Update
January 6 2014
Active Locations (1)
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1
Institute of Food Research
Norwich, Norfolk, United Kingdom, NR4 7UA