Status:
UNKNOWN
Study to Evaluate RAD001 in Combination With Radiotherapy in Non-small Cell Lung Cancer
Lead Sponsor:
Gustave Roussy, Cancer Campus, Grand Paris
Collaborating Sponsors:
Novartis
Conditions:
Non-small Cell Lung Cancer
Locally Advanced Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The phase 1 study evaluats RAD001 in combination with radiotherapy in non-small cell lung cancer. First phase of the study:RAD001 (everolimus) will be administered per os every Monday, one week befor...
Eligibility Criteria
Inclusion
- Unresectable non-small cell lung cancer, stage IIIA/B, or stage IV for which the primary tumor is symptomatic (cough, dyspnea, pain) without extra-thoracic lesions rapidly evolving for which patients should receive radiotherapy at curative dose
- Measurable lesion, documented histologically, potentially accessible during fiberoptic bronchoscopy.
- Age \> 18 years, WHO 0-1,
- Neutrophil count \> 1500 /mm3, Hemoglobin \> 9 g/dL, Platelet count \> 100,000/mm3
- Bilirubin \< 1.5 mg/dL, Transaminases \< 3 N, albumin \>30 g / L, PT \> 70%
- Creatinine \< 120 μM/L
- Patient information and informed consent form signed.
- No previous treatment for lung cancer (surgery, radiotherapy, chemotherapy).
Exclusion
- Patients previously treated with RAD001 (everolimus) or any other mTOR inhibitor
- Stage IV for which the primary tumor is not symptomatic with extra-thoracic lesions rapidly evolving requiring systemic treatment
- Previous radiotherapy,
- Venous or arterial thrombosis, pulmonary embolism during the previous six months
- Concomitant treatment with phenytoin, phenobarbital or any other antiepileptic agent, history of epilepsy
- Concomitant treatment with medicinal products that inhibit, induce or are substrates for CYP3A4(inhibitors: atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, ciclosporin, voriconazoleinducers: rifampicin, carbamazepine, rifabutinsubstrates: midazolam, buspirone, felodipine)
- Concomitant therapy with agents otherwise used in the treatment of cancer (for example methotrexate for rheumatoid arthritis).
- Chronic treatment with corticosteroids or another immunosuppressant
- Patients with an active bleeding diathesis or taking an oral vitamin K antagonist (except low-dose Coumadin (warfarin sodium))
- Other concurrent severe and/or uncontrolled disease which could compromise participation in the study (i.e. uncontrolled diabetes, uncontrolled hypertension, severe infection, severe malnutrition, unstable angina, or congestive heart failure - New York Heart Association Class III or IV, ventricular arrhythmia, active ischemic heart disease, myocardial infarction during the previous six months, chronic liver or renal disease, active upper GI tract ulceration)
- Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of RAD001 (EVEROLIMUS) (i.e. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)
- HIV seropositivity
- Patient with a virological test positive to hepatitis B (HBs positive)
- Patients with active cutaneous, mucosal, ocular or gastrointestinal disorders of grade \> 1
- Previous cancer (except basal cell skin cancer or cervical carcinoma in situ) during the 3 years prior to entering the trial.
- important pulmonary fibrosis on X-ray
- Women who are or could become pregnant or who are currently breastfeeding,
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2014
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01167530
Start Date
March 1 2008
End Date
July 1 2014
Last Update
April 4 2012
Active Locations (1)
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1
Institut Gustave Roussy
Villejuif, France, 94800