Status:
COMPLETED
Anesthesia for Obese Patients: Desflurane Versus Xenon
Lead Sponsor:
Centre Hospitalier Universitaire de Nīmes
Conditions:
Obesity
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Obesity is increasing in France, resulting in an increased demand for bariatric surgery. However obesity also alters physiopathological pathways and the pharmacokinetics of anesthestic agents. The inv...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) I to III
- requires bariatric surgery
- body mass index (BMI) \>= 35 kg/m2
- patient speaks and writes French
- patient has signed consent form
- patient enrolled in a social security program
Exclusion
- patient refuses to sign consent
- ASA IV or more
- patient is pregnant or breastfeeding
- history of hyperthermy (or suspicion, or family history thereof)
- history of liver disease, icterus, unexplained fever, or eosinophilia after administration of a halogen anesthesia
- patient has symptomatic gastro-oesophagean reflux
- patient has hypersensitivity to one or more of the following substances: propofol, remifentanil, celocurine, cisatracurium, rocuronium, desflurane, xenon, paracetamol, ketoprofen, nefopam, tramadol
- patient has obstructive respiratory failure (chronic obstruction pneumopathy, asthma) or has heart disease with severly altered cardiac function
- patient has high intracranial pressure
- patient requires high concentrations of oxygen (fio2\>40%)
- patient has a neuro-sensorial deficient which prevents reading, writing, or response to simple oral commands (severe deafness, language impairment...)in the absence of a prothesis
- patient has a psychiatric pathology, or chronically consumes alcohol or other mind-altering substance
- patient has had general anesthesia in the last 15 days
- patient under guardianship
- impossible to correctly communicate information to the patient
- absence of efficient contraception for women of childbearing age
- participation in another study within the last 3 months
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
192 Patients enrolled
Trial Details
Trial ID
NCT01167803
Start Date
December 1 2010
End Date
December 1 2012
Last Update
March 27 2015
Active Locations (6)
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1
CHU de Clermont Ferrand - Hôpital Estaing
Clermont-Ferrand, France, 63000
2
CHRU de Lille - Hôpital Claude Huriez
Lille, France, 59037
3
CHU de Montpellier - Hôpital Saint-Eloi
Montpellier, France, 34295
4
CHU de Nice - Hôpitaux L'Archet 1 et 2
Nice, France, 06202