Status:
COMPLETED
Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response
Lead Sponsor:
University of New Mexico
Collaborating Sponsors:
Gatorade Sports and Science Institute
Quercegen Pharmaceuticals
Conditions:
Heat Acclimation and Thermotolerance
Eligibility:
MALE
18-39 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I. To ...
Detailed Description
Overall Protocol: This study will involve a repeated-measures design (2 conditions) in which subjects will perform exercise in the heat. Each condition will begin with an Intestinal Permeability Meas...
Eligibility Criteria
Inclusion
- Healthy: 1 or less CV risk factor. Positive risk factors include:
- Family history
- Current cigarette smoker or quit within the previous 6 months
- Hypertension (\>140/90 mmHg) or on antihypertensive medication
- Impaired fasting glucose (\>110 mg/dl)
- Dyslipidemia (LDL\>130 mg/dl;HDL\<40 mg/dl, total \>200 mg/dl)
- Low VO2 peak: \<40ml/kg/min
- Overfatness(BMI\>30 kg/m2 and/or body fat \> 25%)
- Male
- 18-39 years of age
- Willing to follow study diet
- Willing to exercise for prescribed time
- Willing to tolerate hot environment
- Willing to avoid external influences (ambient heat, uv exposure, external exercise) for study duration
Exclusion
- History of heat illness
- Current NSAID use
- Known gastrointestinal disease
- Illness (physician provide physical before subject begin each condition)
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01168739
Start Date
September 1 2009
End Date
March 1 2010
Last Update
March 12 2024
Active Locations (1)
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1
UNM General Clinical Research Center
Albuquerque, New Mexico, United States, 87131