Status:

TERMINATED

An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)- Containing Regimens

Lead Sponsor:

Hoffmann-La Roche

Conditions:

Hepatitis C, Chronic

Eligibility:

All Genders

18+ years

Brief Summary

This observational long-term follow-up study will assess the persistence of direct acting antiviral (DAA) resistant mutations and the durability of sustained virological response in patients with chro...

Eligibility Criteria

Inclusion

  • adult patients, \>/=18 years of age
  • chronic hepatitis C
  • participation in Roche DAA treatment protocol for CHC infection
  • DAA-associated resistant mutations persisting through to last evaluation in donor protocol , or partial viral response or viral load rebound while on RO5024048 treatment, or sustained virological response \>/= 20 weeks after last dose of study medication in donor study

Exclusion

  • For patients participating in DAA resistance monitoring: Initiation of treatment after participation in the donor protocol for which there is evidence of cross-resistance to donor protocol DAA
  • For patients participating in DAA SVR durability: Treatment with any anti-HVC therapy since establishing SVR in the donor study

Key Trial Info

Start Date :

September 1 2010

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

April 1 2015

Estimated Enrollment :

734 Patients enrolled

Trial Details

Trial ID

NCT01168856

Start Date

September 1 2010

End Date

April 1 2015

Last Update

March 11 2016

Active Locations (126)

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Page 1 of 32 (126 locations)

1

La Jolla, California, United States, 92037-1030

2

Long Beach, California, United States, 90822

3

Sacramento, California, United States, 95817

4

Sacramento, California, United States, 95825