Status:
COMPLETED
Effect of Sodium Concentration of Priming and Rinsing Fluids on Weight Gain
Lead Sponsor:
Renal Research Institute
Conditions:
Fluid Overload and Hypertension in Hemodialysis Patients
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Sodium loading during hemodialysis treatment is common and may contribute to increased interdialytic weight gain and hypertension. Excessive use of isotonic saline (containing 0.9% sodium chloride) is...
Detailed Description
This 12 week study consists of 3 phases: Phase 1 (4 weeks): Observation only. Standard priming/rinsing procedure with isotonic saline Phase 2 (4 weeks): Intervention. Switch to a 5% dextrose solution...
Eligibility Criteria
Inclusion
- Ambulatory, clinically stable maintenance HD patients on a thrice weekly HD regimen.
- Willing and able to provide written, signed informed consent after the nature of the study has been explained.
- Willing and able to comply with all study procedures.
- Age ≥18 years.
Exclusion
- Diabetes mellitus
- Considerable residual renal function (diuresis \> 500 mL/day)
- Simultaneous participation in another clinical study except observational trials
- Any psychological condition which could interfere with the patient's ability to comply with the study protocol
- Expectation that native kidney function will recover
- Impossibility to perform a blood pressure measurement on the upper limb
- Unable to verbally communicate in English
- Scheduled for living donor kidney transplant, change to peritoneal dialysis, home HD or plans to relocate to another center during the study period.
- Life expectancy \< 6 months
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT01168947
Start Date
July 1 2010
End Date
November 1 2012
Last Update
April 12 2017
Active Locations (1)
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1
Yorkville Dialysis Center
New York, New York, United States, 10128