Status:
COMPLETED
Biomarkers in Young Patients With Neuroblastoma
Lead Sponsor:
Children's Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Neuroblastoma
Eligibility:
All Genders
Up to 30 years
Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is st...
Detailed Description
OBJECTIVES: Primary * To discover the therapeutically relevant driver mutations in high-risk pediatric neuroblastoma. Secondary * To identify a set of highly annotated neuroblastoma specimens (pri...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Registered on the COG-ANBL00B1 Neuroblastoma Biology Study or its CCG or POG precursor
- Sufficient high-quality tumor material available for the proposed studies meeting the following criteria:
- Tissue histopathologic review with \> 70% tumor cells in sections adjacent to areas used for nucleic acid preparation
- Matched normal cells (blood or uninvolved bone marrow) available
- ≥ 5 μg DNA available
- ≥ 5 μg RNA available
- ≥ 200 mg tissue available
- Tumor samples must meet 1 of the following criteria:
- High-risk tumor
- With or without MYCN amplification
- With or without tumor progression or relapse (during ≥ 2.5 years of follow up)
- Patients aged 18 months to 5 years
- Low-risk tumor
- Primary neuroblastoma
- Stage I disease (completely resected)
- No event in ≥ 3 years of follow up
- Cell lines representing diverse high-risk genetics including with or without MYCN amplification and clinical course (at diagnosis or after relapse)
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
July 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2016
Estimated Enrollment :
380 Patients enrolled
Trial Details
Trial ID
NCT01169376
Start Date
July 1 2010
End Date
May 1 2016
Last Update
May 18 2016
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