Status:
COMPLETED
Cerebral Perfusion Pressure Using Precedex and Other Sedatives
Lead Sponsor:
Duke University
Collaborating Sponsors:
Hospira, now a wholly owned subsidiary of Pfizer
Conditions:
Endotracheal Intubation
Continuous IV Sedation
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.
Detailed Description
Primarily, this study seeks to explore whether there is a difference in mean arterial pressure (MAP) variability, incidence of intracranial hypertension, intracranial pressure (ICP) variability, cereb...
Eligibility Criteria
Inclusion
- Admitted to Duke University Neuro Critical Care Unit (NCCU)
- Adult (18 years of age or older)
- Expected Mechanical Ventilation for \>48 hours with sedation
- Intraventricular catheter in situ
Exclusion
- Hypersensitivity to study drugs
- Prisoners
- Moribund state or death expected within 24 hours
- Surgery planned within 24 hours of subject enrollment
- Receiving study drug, Precedex, prior to entering study
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
89 Patients enrolled
Trial Details
Trial ID
NCT01169467
Start Date
October 1 2009
End Date
November 1 2013
Last Update
November 2 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Duke University Medical Center
Durham, North Carolina, United States, 27710