Status:
COMPLETED
Tracking Inflammatory Cells Using Superparamagnetic Particles of Iron Oxide (SPIO) and Magnetic Resonance Imaging (MRI)
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
Translational Medicine Research Collaboration
British Heart Foundation
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Treatment of a wide range of diseases using stem cells and other types of cell appears promising. Following administration of cells it is often not clear where exactly the cells have gone and how many...
Eligibility Criteria
Inclusion
- Healthy male or female volunteers age 18 to 65 years
- Previous vaccine for tuberculosis more than 5 years ago
Exclusion
- pregnancy / breast feeding
- Contra-indication to MRI scanning
- Inability or refusal to give informed consent
- Renal failure (eGFR \<25mL/min) or hepatic dysfunction (Child's B or C)
- HIV/hepatitis B/hepatitis C/HTLV/syphilis
- Active malignant disease
- Anaemia
- Blood dyscrasia
- High risk of allergy to protamine sulphate (fish allergy, infertile men, vasectomy)
- Known history of tuberculosis infection.
- History of prolonged residence (\> 6 months) in a region or country with a high prevalence of tuberculosis.
- Previous Mantoux reaction of 15mm of greater.
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01169935
Start Date
July 1 2010
Last Update
February 5 2013
Active Locations (1)
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1
University of Edinburgh / Royal Infirmary of Edinburgh
Edinburgh, Scotland, United Kingdom, EH16SU4