Status:
ACTIVE_NOT_RECRUITING
Investigating Genes in Patients With Polymyositis and Dermatomyositis
Lead Sponsor:
Northern Care Alliance NHS Foundation Trust
Conditions:
Myositis
Eligibility:
All Genders
18-70 years
Brief Summary
Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM)belong to a group of inflammatory muscle disorders, of unknown cause, that are characterised by skeletal muscle inflammation an...
Detailed Description
In order to understand the genetic aspects / causes of myositis, and ultimately develop more effective treatment therapies, it will be necessary to collect blood samples and clinical details from arou...
Eligibility Criteria
Inclusion
- Cases must fulfil Bohan and Peter Diagnostic Criteria for Adult PM/DM
- Symmetrical weakness of limb-girdle muscles and/or anterior neck flexors.
- Muscle biopsy evidence typical of myositis.
- Elevation of serum skeletal muscle enzymes.
- Typical EMG features of myositis.
- Typical DM rash, including:
- Probable / definite PM: at least 3 of items 1-4 +ive. Probable / definite DM: item 5 \& at least 2 of items 1-4 +ive.
Exclusion
- Patients below the age of 18 years
- Patients with myositis secondary to alcohol or drug abuse, non abusive drug ingestion (e.g with statins, fibrates etc)
- Patients with myositis following a recent viral illnesses.
- Patients unable to consent for themselves due to diminished mental capacity
- Patients that can not speak sufficiently good English.
- Patients unwilling to give blood sample.
Key Trial Info
Start Date :
January 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT01171573
Start Date
January 1 2001
End Date
December 1 2030
Last Update
April 5 2023
Active Locations (1)
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1
Salford Royal NHS Foundation Trust
Manchester, United Kingdom, M6 8HD