Status:
COMPLETED
Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency
Lead Sponsor:
West China Hospital
Conditions:
Hypertension
Renal Insufficiency
Eligibility:
All Genders
65-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to evaluate the effects of indapamide SR 1.5 mg on renal function, endothelial function, blood pressure variability by comparison with hydrochlorothiazide 25 mg, in patien...
Eligibility Criteria
Inclusion
- Creatinine clearance 30 to 90 mL/min/1.73 m2, with variations of less than 20 percent in the 2 weeks before the screening evaluation.
- Diagnosed hypertension according to guidelines or having taken anti-hypertension drugs.
- Aged between 65 and 85 years.
- Willingness to provide written, informed consent.
- Ability to adhere to study protocol.
Exclusion
- Secondary hypertension.
- Diabetes mellitus.
- Atrial flutter/atrial fibrillation.
- Symptoms of congestive heart failure (NYHA III-IV) or there is evidence that left ventricular EF \< 40%.
- Recent (\< 6 months) myocardial infarction or cerebrovascular ischemic symptoms.
- Recent (\< 3 months) or planned coronary revascularization: PCI (percutaneous coronary intervention)/CABG (coronary artery by-pass graft).
- Severe valvular heart disease.
- History of hypersensitivity to indapamide, thiazides or to any of the components of the products.
- Any current condition or other disease known to interfere significantly with the absorption, distribution, metabolism or excretion of study drugs.
- Participation to another investigational study in the last 3 months.
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT01172431
Start Date
September 1 2010
End Date
December 1 2013
Last Update
June 24 2014
Active Locations (1)
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1
Department of Cardiology, West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041