Status:
UNKNOWN
Study of a Tiotropium Inhaler For Shortness of Breath in Advanced Non-Small Cell Lung Cancer
Lead Sponsor:
Hamilton Health Sciences Corporation
Conditions:
NSCLC
Dyspnea
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The feeling of shortness of breath is very common in lung cancer. It is uncomfortable for patients and upsetting for their family. Although drugs like morphine and oxygen can help some patients feel b...
Eligibility Criteria
Inclusion
- Histologically or cytologically proven incurable stage IIIb or stage IV non-small cell lung cancer.
- Dyspnea as defined by a score of 2 or higher on the 10-point Dyspnea Numeric Scale (Appendix 2).
- New dyspnea or worsening dyspnea within the last 6 months per patient reporting.
Exclusion
- Age \< 18.
- An FEV1 / FVC ratio \< 0.7 with an FEV1 of \< 80% predicted post-bronchodilator.
- Life expectancy \< 3 months.
- Significant worsening of dyspnea over the last week such that an acute cardiac or respiratory condition is considered likely (e.g. pneumonia, heart failure).
- Myocardial infarction within the previous month.
- Heart rate ≥ 120.
- Active tuberculosis or tuberculosis receiving antibiotic therapy.
- Current or previous use of ipratropium, tiotropium, or oxitropium (see Appendix 6).
- Sensitivity to atropine.
- Pre-existing diagnosis of asthma or moderate to severe Chronic Obstructive Pulmonary Disease
- Use of beta-adrenergic bronchodilators more than once per week.
- Use of experimental therapy with known cholinergic or adrenergic effects.
- Uncontrolled glaucoma.
- Urinary retention.
- An active upper or lower respiratory infection or having taken antibiotics for any recent respiratory infection within 4 weeks.
- Symptomatic pleural or pericardial effusion.
- Evidence of reversible proximal endobronchial obstruction.
- Oxygen saturation \< 90%.
- A hemoglobin of \< 100 g/litre. Testing is to be within 4 weeks of randomization.
- Calculated or urine creatinine clearance ≤ 50 mL/min (see Appendix 5 for calculation). Testing it to be within 4 weeks of randomization.
- Weight loss \> 10% of usual body weight within 6 months.
- Known pregnancy or lactating.
- Unable to independently fill out quality of life forms or give informed consent.
- \-
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2016
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01172925
Start Date
November 1 2010
End Date
August 1 2016
Last Update
May 27 2015
Active Locations (1)
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1
Juravinski Cancer Centre
Hamilton, Ontario, Canada, L8V 5C2