Status:
COMPLETED
EAA Intake to Optimize Protein Anabolism in COPD
Lead Sponsor:
Texas A&M University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
Weight loss commonly occurs in patients with chronic obstructive pulmonary disease (COPD), negatively influencing their quality of life, treatment response and survival. Loss of muscle protein is gene...
Detailed Description
In this study the investigators will test the following hypothesis: A high-leucine essential amino acid mixture (dose of 7.0 g EAA + 15 g carbohydrates) will stimulate protein anabolism to a greater e...
Eligibility Criteria
Inclusion
- Diagnosis of chronic airflow limitation, defined as measured forced expiratory volume in one second (FEV1) less than 70% of reference FEV1
- Shortness of breath on exertion
- Age 45 years and older
- Clinically stable condition and not suffering from respiratory tract infection or exacerbation of their disease (defined as a combination of increased cough, sputum purulence, shortness of breath, systemic symptoms such as fever, and a decrease in FEV1 \> 10% compared with values when clinically stable in the preceding year) at least 4 weeks prior to the study
- Ability to lie in supine position for 6 hours
Exclusion
- Established diagnosis of malignancy
- Presence of fever within the last 3 days
- Established diagnosis of Diabetes Mellitus
- Untreated metabolic diseases including hepatic or renal disorder
- Presence of acute illness or metabolically unstable chronic illness
- Recent myocardial infarction (less than 1 year)
- Use of long-term oral corticosteroids or short course of oral corticosteroids in the preceding month before enrollment
- Any other condition according to the PI or study physicians would interfere with proper conduct of the study / safety of the patient
- Failure to give informed consent
Key Trial Info
Start Date :
September 8 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 17 2012
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01173354
Start Date
September 8 2009
End Date
February 17 2012
Last Update
September 30 2025
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205