Status:
WITHDRAWN
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
Lead Sponsor:
ResMed
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Respiratory Failure
Neuromuscular Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic re...
Detailed Description
The aim of the study is to compare the effect of two types of noninvasive ventilator (a small machine that assists breathing) in patients admitted to hospital with a sudden worsening of their existing...
Eligibility Criteria
Inclusion
- patients admitted or transferred to Royal Brompton Hospital with acute exacerbation of chronic respiratory failure, or inpatients who suffer a deterioration in respiratory status, defined as 7.25 \< pH \< 7.35, PaCO2 \> 6.0kPa, and respiratory rate \> 20bpm
Exclusion
- \< 18 years old
- pH \< 7.25
- need for immediate intubation
- uncontrolled cardiac failure
- hypotensive (systolic blood pressure \< 90mmHg)
- acute myocardial infarction
- acute dysrhythmia
- other system failure (e.g. acute renal failure, liver failure)
- moderate or severe bulbar weakness
- inability to understand rationale and/or consent form for study
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 10 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01174316
Start Date
August 1 2010
End Date
May 10 2011
Last Update
April 19 2021
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6NP