Status:
WITHDRAWN
New Castle Disease Virus (NDV) in Glioblastoma Multiforme (GBM), Sarcoma and Neuroblastoma
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Glioblastoma
Sarcoma
Eligibility:
All Genders
3-75 years
Phase:
PHASE1
PHASE2
Brief Summary
Patients with specific metastatic cancers who failed prior therapeutic regimes will be treated with NDV for at least a year or until disease progression. The study will measure progression-free diseas...
Detailed Description
Present therapeutic regimes have not much improved the survival of patients with metastatic cancer. Therapeutic cancer vaccines are a form of immunotherapy designed to educate the immune system to rec...
Eligibility Criteria
Inclusion
- Evidence of progressive disease in the above categories evaluated by standard tumor staging.
- Histologically confirmed diagnosis.
- Failure of conventional anti- cancer modalities.despite optimal application of all relevant available anti- cancer modalities.
- Age between 3 and 75 years old.
- Liver function tests less than twice the normal, renal function no more than 20% reduction and white cell and platelets count no more than 30% reduction.
- Karnofsky performance status of 50% or greater
- A written informed consent understood and signed by the patient and by a spouse, parent or guardian. In patients with GBM two signs will be required due to possible alterations of psych and understanding.
Exclusion
- Not fulfilling any of the above criteria
- Moribund patients or patients with life- expectancy \< 3 months
- Karnofksy performance status \< 50%
- Pregnant or lactating women
- Active local or systemic infections requiring treatment
- Patients receiving other investigational agents
- History of allergy to egg ova-albumin.
- Co-morbidity or life- threatening clinical condition other than the basic cancer
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01174537
Start Date
July 1 2011
End Date
July 1 2011
Last Update
June 11 2015
Active Locations (1)
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1
Hadassah Medical Organization
Jerusalem, Israel, 91120