Status:
COMPLETED
Stress, Hormones, and Eating
Lead Sponsor:
University of California, San Francisco
Conditions:
Food Addiction
How Opioid Tone Was Related to Self Reported
Eligibility:
FEMALE
20-45 years
Phase:
EARLY_PHASE1
Brief Summary
The investigators will develop a measure of endogenous opioid tone that might serve as a biological marker for drive for palatable food. Using a 'naltrexone probe,' the investigators will assess wheth...
Detailed Description
Opioid tone may provide a way to identify people at risk of reward based eating, with more accuracy than self-report measures. Knowing such risk could improve treatment matching, and provide a biomark...
Eligibility Criteria
Inclusion
- Women
- Age \> 20 to 45 years (pre-menopausal women)
- BMI \> 30 and no larger than BMI = 40 or 300 pounds
Exclusion
- Inability to provide informed consent or speak English
- Needle phobic or fainting in response to blood draw
- Diabetes
- Currently pregnant or breastfeeding
- Currently Smoke
- Bulimia (Binge Eating Disorder is common among the obese, and allowed)
- Pacemaker
- Shift Worker
- Beta Blocker Medication use
- Liver Medication use
- Weight Loss Medication use
- Chronic current use of cortisol containing medications
- Kidney Disease (based on elevated Blood Urea Nitrogen and Creatinine)
- Illegal Drug Use (presence in urine)
- Liver Cirrhosis or Acute hepatitis (based on elevated Alanine transaminase)
- Substance abuse, mental health, or medical condition that, in the opinion of investigators, will affect study outcomes (e.g., hypertension, severe food allergies).
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT01175512
Start Date
July 1 2010
End Date
December 1 2011
Last Update
January 28 2021
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