Status:
COMPLETED
Detection of Human Beta Cell Death in Type 1 Diabetes Mellitus (T1DM) by Methylation Specific Polymerase Chain Reaction (PCR)
Lead Sponsor:
City of Hope Medical Center
Conditions:
Type 1 Diabetes Mellitus
Eligibility:
All Genders
18+ years
Brief Summary
To investigate the use of methylation-specific PCR (MSP) assays to detect human beta cell-specific gene methylation patterns in serial blood samples drawn from newly diagnosed Type 1 diabetics.
Detailed Description
The study will follow 25 newly diagnosed type 1 diabetic patients from the onset of symptoms to one year post-diagnosis. A total of 11 fasting blood draws will be taken, the first near the time of dia...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Healthy volunteers:
- Age \> 18 years of age,
- Otherwise healthy individuals with no cancer and not pregnant.
- Type 1DM:
- Newly diagnosed type I diabetes,
- Age \> 18 years of age,
- Otherwise healthy individuals with no severe complications, no cancer, not pregnant,
- Willing and able to comply with the scheduled visits to the clinic for blood sampling,
- Remain under the continuing care of an Endocrinologist.
Exclusion
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT01176253
Start Date
July 1 2009
End Date
April 1 2015
Last Update
May 1 2015
Active Locations (2)
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1
City of Hope National Medical Center-Department of Diabetes, Endocrinology, & Metabolism
Duarte, California, United States, 91010
2
Loma Linda Medical Center
Loma Linda, California, United States, 92354