Status:
COMPLETED
Investigating the Inotropic Potential of Apelin
Lead Sponsor:
University of Edinburgh
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The apelin-APJ system is a recently discover hormone system that has several important actions in the cardiovascular system. Apelin causes the heart pump with more force and also causes blood vessels ...
Eligibility Criteria
Inclusion
- Healthy volunteers:
- \>18yrs
- Heart failure patients;
- New York Heart Failure class II-IV
- Ejection fractional \<35% or fractional shortening \<20% within previous 6months.
Exclusion
- All subjects,
- Females of child bearing age not on adequate contraception
- Lack of informed consent
- Age \<18yrs
- Current involvement in any other research study
- Systolic BP \>190 or \<100
- Malignant arrhythmias
- Renal or hepatic failure
- Haemodynamically significant aortic stenosis
- Severe or significant co-morbidity
- Pacemakers
- Healthy volunteers
- Any regular medication
- Previous history of any cardiovascular disease
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01179061
Start Date
August 1 2010
End Date
July 1 2012
Last Update
May 9 2024
Active Locations (3)
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1
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc
Edinburgh, United Kingdom, EH16 4SA
2
Gareth Barnes
Edinburgh, United Kingdom, EH16 4SA
3
University of Edinburgh
Edinburgh, United Kingdom, EH16 4SA