Status:
COMPLETED
Combined FDG PET/CT Imaging in Response Evaluation After Radiochemotherapy in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Lead Sponsor:
University Hospital, Antwerp
Collaborating Sponsors:
Agentschap voor Innovatie door Wetenschap en Technologie
Conditions:
Locally Advanced Squamous Cell Carcinoma of the Head and Neck Region
Eligibility:
All Genders
18+ years
Brief Summary
To determine if combined \[18F\]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is performant enough with respect to detecting residual lymph node involvement ...
Detailed Description
Patients with locally advanced, N2 and N3 head and neck squamous cell carcinoma (HNSCC) will be recruited. All subjects receiving induction chemotherapy will undergo a baseline integrated \[18F\]fluor...
Eligibility Criteria
Inclusion
- Patients with locoregionally advanced HNSCC (clinically and/or radiological N2 or N3 disease, any T stage) with no evidence of distant metastases, scheduled for concurrent chemoradiation and being potential candidates for a subsequent neck dissection.
- Induction chemotherapy is allowed if this approach is followed by concurrent chemo-radiation.
Exclusion
- Other head and neck cancer histologies
- Upfront inoperable patients in the neck (eg. carotid invasion)
- Presence of distant metastases
- A history of another primary malignancy, except when disease-free for at least 5 years after radical treatment, or except for treated basaloid skin cancer or in situ carcinoma of the cervix
Key Trial Info
Start Date :
February 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT01179360
Start Date
February 1 2011
End Date
December 1 2015
Last Update
November 17 2017
Active Locations (3)
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1
Antwerp University Hospital
Edegem, Antwerp, Belgium, 2650
2
AZ Turnhout
Turnhout, Antwerp, Belgium, 2300
3
Academisch Ziekenhuis Vrije Universiteit Amsterdam
Amsterdam, Netherlands, 1081HV