Status:
COMPLETED
Vitamin D Supplementation and Physical Function in Older Adults
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Physical Function
Vitamin D Insufficiency
Eligibility:
All Genders
70-89 years
Phase:
EARLY_PHASE1
Brief Summary
A growing body of evidence suggests that vitamin D status is important in biologic processes involved in the maintenance of physical function. To advance the investigators understanding of the role of...
Detailed Description
A growing body of evidence suggests that vitamin D status is important in biologic processes involved in the maintenance of physical function. However, whether remediation of vitamin D insufficiency w...
Eligibility Criteria
Inclusion
- Short Physical Performance Battery (SPPB) score of ≥ 4 to \< 10
- Vitamin D insufficient (serum 25(OH)D ≥ 10 to \< 25 ng/mL)
Exclusion
- Serious or uncontrolled chronic disease including: insulin-dependent or uncontrolled diabetes; cancer requiring treatment in past year, except non-melanoma skin cancers; past or current ischemic heart disease, uncontrolled angina, heart failure, peripheral artery disease (PAD), or stroke; chronic respiratory disease; uncontrolled endocrine/metabolic disease; neurological or hematological disease; liver or renal dysfunction; and severe musculoskeletal impairment
- Impaired cognitive function (MMSE ≤ 24)
- Dependent on a cane or walker
- Use of anti-coagulants
- Unwillingness to undergo a muscle biopsy
- Taking prescription vitamin D2 or OCT vitamin D3 supplements of \> 1000 IU/d
- Inability or contraindications to consume daily vitamin D and calcium supplements
- Weight loss of ≥ 5% or more in the past 6 months
- Involved in any other intervention
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01179503
Start Date
January 1 2010
End Date
May 1 2011
Last Update
August 17 2018
Active Locations (1)
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1
Wake Forest University
Winston-Salem, North Carolina, United States, 27157