Status:
COMPLETED
Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal Surgery
Lead Sponsor:
Huazhong University of Science and Technology
Conditions:
Pain
Surgery
Eligibility:
All Genders
20-65 years
Brief Summary
Purpose: This study aimed to investigate the impact of CYP3A4\*1G genetic polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery. Methods: 176 patients receiving...
Eligibility Criteria
Inclusion
- Aged 20-65 years
- Anesthesiologists (ASA) physical status I or II;
- With ±20% of ideal body weight;
- Received PCA administration;
- Agreed to participate the research
Exclusion
- History of chronic pain;
- Psychiatric diseases;
- Diabetes mellitus;
- Severe cardiovascular diseases;
- Kidney or liver diseases;
- Alcohol or drug abuse (according to the criteria of DSM-IV);
- Pregnancy or at lactation period;
- Consumed drugs (1week) or foods (3 days) known to inhibit or induce the expression of CYP3A4 enzymes prior to surgery;
- Refused PCA administration;
- Disagree to participate to the research
Key Trial Info
Start Date :
November 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
176 Patients enrolled
Trial Details
Trial ID
NCT01181492
Start Date
November 1 2008
End Date
April 1 2010
Last Update
November 1 2013
Active Locations (1)
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1
1. Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030