Status:
COMPLETED
Lung Inflammation and Lung Metastases From Breast Cancer
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Collaborating Sponsors:
Weill Medical College of Cornell University
Vanderbilt University
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
The purpose of this study is to find out if there is a link between cigarette smoking, inflammation and the spread of breast cancer to the lung. We think that women who are current or former smokers m...
Eligibility Criteria
Inclusion
- Registered patient at MSKCC
- Histologically proven breast cancer. It is not necessary that pathology be reviewed at MSKCC
- Age ≥18 years Group 1 (A and B)
- Diagnosed with metastatic breast cancer on biopsy or imaging study.
- Patients will be considered to have lung metastases, and will be assigned to group 1A if any of the following criteria are met, otherwise patients will be assigned to group 1B "No known Lung Metastases," Biopsy-proven lung metastasis.
- Pleural effusion with cytologic evidence of malignancy.
- Pleural effusion, exudative in character, without alternative explanation and attributed, in the opinion of the clinician to metastatic disease.
- Symptoms attributable to lung metastases and a radiological pattern interpreted by a radiologist as suspicious for metastatic disease.
- Any pulmonary nodule on chest radiograph, CT scan, PET-CT or MRI, which is interpreted by the clinician and radiologist to be metastatic in etiology, whether or not a biopsy was performed, and regardless of symptoms.
- A radiographic pattern interpreted by a radiologist as consistent with lymphangitic carcinomatosis.
- Group 2 (Controls)
- History of early breast cancer and currently no evidence of disease
Exclusion
- Inability to provide written informed consent.
- Inability to complete smoking and NSAID questionnaire.
- Steroid use within the previous 4 weeks.
- Radiotherapy to the breast, chest wall or axilla within the previous 3 months.
- Men with breast cancer.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT01182519
Start Date
August 1 2010
End Date
July 1 2016
Last Update
July 12 2016
Active Locations (1)
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1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065