Status:
COMPLETED
Watermelon Supplementation and Arterial Stiffness
Lead Sponsor:
Florida State University
Conditions:
Hypertension
Eligibility:
All Genders
45-70 years
Phase:
PHASE1
PHASE2
Brief Summary
Increased abdominal obesity (waist circumference) and systolic blood pressure (BP) are main risk factors for the metabolic syndrome. Approximately 60% of adults in the United States are prehypertensiv...
Detailed Description
The purpose of the study is to examine the effect of 12 weeks of L-citrulline/L-arginine in the form of watermelon supplementation on arterial function and autonomic neural control of the heart rate a...
Eligibility Criteria
Inclusion
- Thirty men and women 45-70 years of age
- BP between 120-159/80-99 mmHg
- Waist circumference \>102 cm in men and \> 80 cm in women
Exclusion
- BP \>160/100 mmHg
- Asthma
- Glaucoma
- Herpes simplex
- Uncontrolled diabetes
- Neurological disease
- Cardiovascular disease
- Inflammatory disease
- Kidney disease
- Hormone replacement therapy (HRT)
- Amino acid/vitamin supplementation\\
- Corticosteroids or non-steroidal anti-inflammatory drugs
- Any drug known to affect BP or heart rate
- Glycemic control drugs
- Lipids reducing drugs
- Participants should not consume \> 12 alcoholic drink/week
- Smokers
- Regular Exercisers (= 1.5 hour/week).
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01185041
Start Date
August 1 2010
End Date
August 1 2011
Last Update
March 20 2012
Active Locations (1)
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1
Cardiovascular Physiology Laboratory
Tallahassee, Florida, United States, 32306