Status:
UNKNOWN
Investigation of Alanine in Fructose Intolerance: A Dose Ranging Study
Lead Sponsor:
Augusta University
Collaborating Sponsors:
University of Iowa
Teikyo University
Conditions:
Fructose Intolerance
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Background: Over the past few decades, fructose is increasingly being used as a sweetener/ additive in a variety of foods. Incomplete absorption of fructose has been implicated as a cause of gastroin...
Eligibility Criteria
Inclusion
- Age between 18-70 years
- Diagnosis of fructose malabsorption (positive breath test after ingestion of 25 grams of fructose defined as either (a) ≥ 20 ppm rise of breath H2/CH4/both over baseline values or a successive rise of ≥ 5 ppm over baseline and in 3 consecutive breath samples)
Exclusion
- Cognitive impairment or any other inability to provide informed consent
- Prisoners
- GI surgery except appendectomy, cholecystectomy, caesarean section, hysterectomy
- Antibiotics in the previous 3 months
- Bacterial overgrowth or lactose intolerance
- Major co-morbid illnesses, including chronic pancreatitis, celiac disease, inflammatory bowel disease, diabetes, scleroderma, pseudo-obstruction syndromes etc.
- Known food allergies
- Medication use: opioids, Tegaserod, laxatives, enemas
- Diabetes
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01185210
Start Date
September 1 2007
End Date
April 30 2024
Last Update
July 21 2022
Active Locations (1)
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1
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242