Status:
COMPLETED
Microparticles in Stored RBC as Potential Mediators of Transfusion Complications
Lead Sponsor:
University of Miami
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Coronary Artery Bypass
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
INTRODUCTION. Cell-derived microparticles (MP) are released in cell activation, apoptosis and other processes. MP derived from red cells (RMP) are known to be released from stored packed red blood cel...
Detailed Description
1. Study Design. 1.1. Patient population. More than 500 coronary artery bypass surgeries (CABG) are performed annually at Jackson Memorial Hospital (JMH), the main teaching hospital of the U of M ...
Eligibility Criteria
Inclusion
- Patients requiring coronary artery bypass (CABG) surgery will be enrolled into the study if they: (1) are willing and able to give informed consent and to adhere to study follow up requirements; and (2) do not satisfy any of the exclusion criteria
Exclusion
- Patients will be ineligible for the study if they (1) are unable or unwilling to give informed consent; (2) are unable or unwilling to follow the study protocol; (3) are less than 21 years of age; (4) require emergency procedures; (5) require cardiopulmonary bypass (pump) during the operation; (6) require other surgical procedures in addition to coronary artery bypass; (7) have a proven coagulation or platelet disorder; (8) are unwilling to receive blood transfusions; (9) are pregnant; or (10) have cognitive impairment.
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
177 Patients enrolled
Trial Details
Trial ID
NCT01185600
Start Date
July 1 2010
End Date
May 1 2015
Last Update
July 2 2017
Active Locations (1)
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1
Jackson Memorial Hospital
Miami, Florida, United States, 33136