Status:
COMPLETED
Prospective Longitudinal Study of Patients With Idiopathic Pulmonary Arterial Hypertension, Family or Taking Anorectics
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Pulmonary Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this clinical research is to analyze the survival of a cohort of patients newly diagnosed (incident cases) with idiopathic PAH, familial or associated with the use of anorectics (isol...
Detailed Description
Pulmonary arterial hypertension (PAH) is a rare disease characterized by an intense proliferation of pulmonary arterial wall causing increased progressive pulmonary vascular resistance, leading to rig...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Man or woman aged over 18 years
- With pulmonary arterial hypertension (PAH) idiopathic, hereditary or associated with the use of anorectics, newly diagnosed (less than 6 months) whose diagnosis was made by cardiac catheterization finding a mean pulmonary arterial pressure (mPAP)\> 25 mm Hg at rest or\> 30 mm Hg during exercise, with a pressure pulmonary artery occlusion (PAOP) ≤ 15 mm Hg,
- Has given his free and informed consent.
- Exclusion criteria:
- Minor (age \<18 years)
- PAH patients whose diagnosis was there more than 6 months (prevalent cases),
- Patient with PAH associated with concomitant disease (autoimmune disease, portal hypertension, HIV infection, congenital heart disease, schistosomiasis, chronic hemolytic anemia)
- Patient with veno-occlusive disease and / or pulmonary capillary hemangiomatosis suspected or documented
- Patients with pulmonary hypertension associated with left heart (pulmonary hypertension post-capillary)
- Patients with pulmonary hypertension associated with respiratory disease (chronic obstructive pulmonary disease, pulmonary fibrosis, sleep apnea syndrome Sleep)
- Patients with pulmonary hypertension post-embolic chronic
- Patient with pulmonary hypertension associated with sarcoidosis, histiocytosis X, a Lymphangioleiomyomatosis to mediastinal fibrosis,
- Adults protected
- Pregnant or lactating
- Persons deprived of liberty
- Persons in emergency situations,
- Persons who refused or unable to give informed consent.
- No affiliation to a social security scheme (beneficiary or beneficiary)
Exclusion
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
165 Patients enrolled
Trial Details
Trial ID
NCT01185730
Start Date
January 1 2011
End Date
January 1 2016
Last Update
April 11 2016
Active Locations (1)
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1
Hôpital Bicêtre
Le Kremlin-Bicêtre, France, 94275