Status:

COMPLETED

Exercise Oscillatory Breathing and Sildenafil in Heart Failure

Lead Sponsor:

University of Milan

Conditions:

Heart Failure

Eligibility:

MALE

30-80 years

Phase:

PHASE2

Brief Summary

Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in approximately 20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pathophysiology seems quit...

Eligibility Criteria

Inclusion

  • consent to participate in the study after detailed information about benefits and risks
  • negative exercise stress test prior to study initiation
  • forced expiratory volume in 1 sec/forced vital capacity ratio \>70%;
  • LVEF \< 45%.

Exclusion

  • inability to complete a maximal exercise test
  • resting systolic blood pressure \> 140 or \<110 mmHg
  • therapy with nitrate preparations
  • history of sildenafil intolerance
  • significant lung or valvular diseases
  • neuromuscular disorders or peripheral vascular disease

Key Trial Info

Start Date :

April 1 2008

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

June 1 2010

Estimated Enrollment :

32 Patients enrolled

Trial Details

Trial ID

NCT01185925

Start Date

April 1 2008

End Date

June 1 2010

Last Update

August 5 2011

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