Status:
COMPLETED
Chronic HIV Infection and Aging in NeuroAIDS (CHAIN)
Lead Sponsor:
University of Nebraska
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
HIV
Aging
Eligibility:
All Genders
20-75 years
Brief Summary
The purpose of this study is to find the best tests to use to investigate the differences between older and younger people with HIV disease. Test to be included will measures of memory, learning, acti...
Detailed Description
Advances in the treatment of chronic HIV disease over the last 20 years have resulted in dramatic declines in morbidity and mortality. However, emerging data suggest that chronically infected patients...
Eligibility Criteria
Inclusion
- Diagnosed with HIV infection.
- 20-40 years of age or older than 50.
- If taking antiretroviral therapy, on stable therapy for the past 12 weeks and not anticipated to require a change in therapy during the following 6 weeks.
- If not taking antiretroviral therapy, not anticipated to initiate therapy in the next 6 weeks.
- Ability to provide written informed consent.
- Ability to complete the questionnaires in English.
Exclusion
- Completion of treatment for any intercurrent acute infection less than four weeks before study entry. Maintenance or prophylactic therapy is permitted for opportunistic infections.
- Any active psychiatric illness including schizophrenia, severe depression, or severe bipolar affective disorder that, in the opinion of the investigator, could confound performance of or the analysis of the test results.
- Active drug or alcohol abuse that, in the investigator's opinion, could compromise compliance with study procedures or confound the analysis of the test results.
- Major neurologic disease such as multiple sclerosis or stroke, active brain infection (except for HIV-1), brain neoplasm, or space-occupying brain lesion.
- Current delirium or intoxication.
- Pregnancy.
- Any other condition that, in the opinion of the investigator, is a contraindication to participation.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 17 2014
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01186042
Start Date
August 1 2010
End Date
December 17 2014
Last Update
September 6 2023
Active Locations (1)
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1
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198