Status:
COMPLETED
Morphine In Acute Myocardial Infarction
Lead Sponsor:
French Cardiology Society
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether intracoronary injection of morphine chlorhydrate is effective to limit ischemia-reperfusion lesion during percutaneous coronary angioplasty in patient...
Eligibility Criteria
Inclusion
- Acute Myocardial Infarction less than 6 hours defined by
- prolonged chest pain (\>15 min)
- in association with
- ST elevation 1mm or more in two contiguous leads
- or occurence of Q wave in three contiguous leads
- or occurence of left bundle branch block
- Culprit lesion eligible for percutaneous coronary intervention (PCI)
- TIMI flow 0 before PCI
Exclusion
- Fibrinolysis
- Allergy to morphine
- Active epilepsy
- Brain injury or intracranial hypertension
- Previous AMI, coronary artery bypass graft (CABG)
- Cardiac arrest
- Cardiogenic shock, significant mitral regurgitation or intraventricular communication at inclusion
- Mechanical ventilation at inclusion
- Significant ventricular arrhythmia or atrioventricular block type II or III at inclusion
- Decompensated chronic obstructive pulmonary disease at inclusion
- chronic hepatocellular failure
- MRI contraindications
- Gadolinium chelates injection contraindications
- Current treatment with morphine chlorhydrate, buprenorphine, nalbuphine, pentazocine
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT01186445
Start Date
January 1 2011
End Date
December 1 2016
Last Update
February 6 2017
Active Locations (2)
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1
Henri Mondor Hospital
Créteil, France, 94010
2
Hopital Marie Lannelongue
Le Plessis-Robinson, France, 92350