Status:
COMPLETED
Effects of Continuous Nerve Block vs Single Injection Block With PCA vs PCA on Pain and Function After Knee Replacement
Lead Sponsor:
Tan Tock Seng Hospital
Conditions:
Pain
Eligibility:
All Genders
40-90 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the effectiveness of three analgesia techniques on pain relief and functional recovery after knee replacement: continuous femoral nerve block vs single-injectio...
Detailed Description
Primary Outcome Measures: * Incidence of patients with significant pain on movement on day 1 post surgery * Range of knee flexion Secondary Outcome Measures: * Pain intensity (rest/movement) * Func...
Eligibility Criteria
Inclusion
- 40 years and above
- Osteoarthritis
- Primary unilateral total knee replacement
- No other lower extremity joint disease
- ASA I-III
- Body mass index \< 35
- No severe cardiac or pulmonary diseases
- No chronic narcotic therapy or illicit drug use
- Mentally competent to understand study procedures and use of pain scales
- Able to provide informed consent
Exclusion
- Any cause for knee replacement other than osteoarthritis
- Total knee revision
- Any contraindication for femoral block
- Abnormal coagulation studies
- Thrombocytopenia less than 100,000/cc
- Known hepatic or renal insufficiency
- Neurological disease involving lower extremities
- Major surgery during the last 2 weeks pre-operatively
- History of allergy to study medications
- History of post-operative bleeding over 2000 cc/24 hours
- History of opioid or alcohol abuse
- Currently taking or has taken opioid \> 30 consecutive days of daily use at a daily dose \> 15mg morphine, within the past 2 weeks prior to surgery
- Previously has not responded to opioid analgesics for treatment of pain
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01187537
Start Date
July 1 2009
End Date
December 1 2011
Last Update
May 13 2016
Active Locations (1)
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1
Tan Tock Seng Hospital
Singapore, Singapore